Nimbus - Excellent questions. My onc always told me, "It's the TKI, not the CML" whenever I complained of anything, especially fatigue. On that, he also said, "ALL my CML patients on ALL the TKI's have fatigue." So. There's that, for whatever it's worth. I have always wanted to know WHY and HOW the TKI's cause their problems, and not one doctor has ever told me. BUT, Trey has, and after a lot of digging into science papers, I've figured some reasons out. Across the board, no matter what's bothering you, it's likely due to the accidental targeting of healthy cellular systems at the same time our CML system is being targeted. So, because of hitting PDGFR kinase, we get wonky interstitial cell fluid balances - boom, edema. Especially periorbital, because - surprise! - also affected is collagen structure, and the already weakest places for support (like eyelids) let that edema in. Melanin production is also accidentally swept up and hit, hence the super pale skin we get and the difficulty of getting tanned. ATP is crucial to cell metabolism - using fuel for energy - so why would we be surprised that hitting CML's ATP in order to knock it out would also mess with our energy level overall, since healthy cells' ATP is getting hit, too. There are lots more, but "they" never tell us. I suspect that's because they don't have an ironclad causative linear proof - it's just suspicious and plausible. Anyway, it makes me feel better to know that there's a reason, and I'm not crazy. Now, your other question about long-term effects of leukemia - that one is truly a biggie. Some people think the normal population has some Philadelphia chromosome/ABR-BCL and it's just below the radar of a PCR. And what about equating "undetectable" with MR4.5 (0.0032% IS) - if even the teensiest bit is there, is there potential for trouble later? Or is it as good as dead and your immune system will keep it that way forever? Wow, dunno.