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MMR lost

My pcr test in October of last year was 0.0025 and now it is 0.2425. Ive been on gleevec since 2005 and within the last 2 years switched to the generic brand. Will one of the other drugs bring the numbers back down and which one do they usually switch you to.

Rsgiles - That is a big jump and could easily be lab error. I would first test again to verify the measurement is correct.

Assuming it is correct, consider switching to a low dose dasatinib (20 mg). Verify results after 3 months that you are back below MMR. There is a very good chance that dasatinib will work for you and drop your counts to "undetected". A low dose is best to start so you minimize side effects (you won't feel any) and get a better response. You can always increase dose later (40 or 50 mg) if 20 mg is not sufficient. In the case of dasatinib, you want to take the lowest dose possible that works. Once that threshold is achieved, more drug does not lead to better response but can easily lead to more side effects (pleural effusion).

Dasatinib attacks CML differently than either gleevec or tasigna by killing higher order CML cells.

Thanks i hope it is an error because at the same time I just got told I have type 2 diabetes and now dont feel good because of that medicine. My glucose reading was 297 but now I have it down into to 80-90. that was two weeks ago.

Regarding your diabetes:

Type 2 (non-insulin dependent) diabetes occurs through lifestyle and diet. Genetics influences whether we are able to withstand our life choices or not, but type 2 can be reversed.

Our bodies have 3 places where "sugar" is drawn out of the blood using the action of insulin. Skeletal muscle, liver and fat. All three sites have differing responses to insulin in controlling sugar, but the liver is the big gun. The liver both takes up sugar, releases sugar and converts sugar to fat. Fat cells will take up sugar and convert to fat. Muscles take up both sugar and fat, but will burn lots of sugar if they are working hard.

Type 2 diabetes results when the pancreas can no longer provide enough insulin to shut down the liver from releasing sugar. And the liver will make sugar not just release.

So what is the solution - reverse the process. Go into a calorie deficit. Eliminate carbs (< 20 grams a day, which is nothing) and eat protein sparingly. Going without food (water only fast) is the fasted way to reverse diabetic conditions. It's not easy at first, but gets very easy with time (body adapts).

Once your body has no carbs and has to burn more calories than it takes in, the liver starts to burn fat for fuel. The body enters ketosis.

The age old saying, "diet and exercise" is absolutely true. Cut out the carbs and do some exercise - ANY exercise is good. Weight bearing exercise is best (pushups, situps, etc. or better weight lifting)

The exercise part of this is to create a "sink" for the extra sugar in your blood. When your muscles are stressed during weight bearing exercise, they put out the shovel for sugar and deplete the blood of it and make it easier for your pancreas to keep sugar levels steady. When muscles are quiet, they burn fat mostly, but very slowly. Exercise is a great way to clean out the liver of excess fat and sugar BUT ONLY if you are not overfeeding yourself. Over time, your liver clears the fat out and responds better to insulin telling it to stop making sugar. Any long term fast should be done under the supervision of a wellness doctor who knows how to guide you.

 

 

 

I did lose about 20 pounds so far since 5 months ago. I cut almost all carbs and eat a lot of vegetables and chicken and fish but not that much. thanks for your help.