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Nilotonib and inflammation

Hello to all

have any of you that have taken Nilotonib been tested and diagnosed with chronic inflammation as a side effect of the medication ?

im currently having problems with lower limb joint pain and excessive amounts of fatigue that I’m trying to find the cause of as it’s progressively worsening. 
 

thank you 😊 

Hi

If you look at the side effect profiles of many of the tkis then joint pain,muscle issues and cramp are fairly common especially if one is a long term user.I have non diabetic peripheral neuropathy where the nerves at the extremities start to break down especially in the feet-a good indicator of inflammation is CK or creatine kinase levels in the blood;very high CK levels can affect the heart muscles and also the brain in extreme cases.Do you have a CK score?

I wonder if you have had your Vit D level tested ;in addition you might find that taking a magnesium and calcium supplement will help as well as getting moderate exercise.There is increasing evidence that lifestyle factors affect wellbeing post- diagnosis with many cancers and one might be advised to concentrate on foods that reduce inflammation-nuts,fish veg and fruit and cut out processed nasties,trans fats and lots of animal foods/fats-especially meats produced using hormones and antibiotics in the rearing process.

Best wishes

John

Thanks for the reply John

My lifestyle is pretty much follows the same advice in your reply.  I don’t recall getting a CK blood test so that may be worth checking.

what symptoms do you get in your lower limbs from the peripheral neuropathy?  
 

regards 

Mick

Johnw1001 is right on the mark. Lifestyle affects the impact of side effects of TKI. I was on Imatinib for years and struggled with inflammation issues mostly related to my spine. After coming up with an effective exercise regimen the effects were less. I am on nilotinib now and while the back issues have receded a bit the lower extremities have flared up to a point I thought I had gout. I added balance and toe lifts to my exercise routine and that has helped. Nilotinib seems to have a different affect on me I struggle with itchy scalp, constipation, and dry eyes. Fatigue does get me every once in a while.

Totally agree lifestyle is very important, even without this condition!  Its very easy to blame meds for all the aches and pains but sometimes we have to take responsibility for self inflicted health issues! 
I’ve recently had tests for some of my major concerns with Nilotonib but I’ve only recently seen that it can cause low level chronic inflammation in some cases. Like yourself I get gout symptoms in my hand and feet which can also be associated with inflammation.