Curcumin vs. Aspirin vs. Ibuprofen

Hi Scuba,

Perhaps it would be wise to consider each of the parameters inflammation,blood thinning,oxidative stress and cancer prevention in the context of one who has for whatever reason been unfortunate as we have contracted CML .For me it is a bit of well if I had known then what I know now I would perhaps have been able to be in position to have avoided being a CML sufferer via diet, lifestyle and perhaps some appropriate pills!.So for us it is too late and now post dx all we can do is to try to stay as healthy as possible perhaps!

In terms of inflammation it seems that we can reduce this via diet or pills or both.I have just skimmed through the book by Dan Buettner on The Blue Zones where basically he considers 5 blue zones Sardinia,Okinawa Costa Rica, Greece and one in USA where by way of diet and healthy lifestyle residents appear to be living the longest via an anti inflammatory diet.

I take turmeric on a regular basis as a health supplement but would be wary of taking aspirin because of its blood thinning effects as it might lead to internal bleeding and if i was on Dasatinib I would avoid it as at times due to its interaction with the tki.I take edoxoban (it is a direct oral anti coagulant {DOAC} that is easier to use and monitor than warfarin)  as a blood thinner under medical supervision as this in my old age hopefully should minimise risks of a stroke.Imatinib can potentiate imatinib so one has to be careful to avoid major cuts and monitor platelets on a regular basis.

I would very much avoid ever using ibuprofen because research at Universiity of Adelaide has indicated that this compound interacts with tkis and especially imatinib to influence uptake of the tki.

The Blue Zones found that goats milk is anti inflammatory and pasture fed sheeps cheese is very high in omega 3 s.Dark honey slows the oxidation of bad cholesterol in the blood.General rules from the long livers was to have a plant slant and to eat slow as well fronting each meal with beans and tofu.

As a summary foods that could be anti inflammatory or  reduced oxidative stress were cooked corn,turmeric/ginger,herbs ,veg,nuts and seeds,oranges greens ,black tea etc.Vitamin D plus adequate calcium levels were also in the forefront.

In the past my practice nurse said to me- OK if you want to be faddish it is up to you.Some medics take time to try to educate their patients in healthy diet and lifestyle -some give up and just dispense the pills or offer dietary advice  and the pills.The problem as I see it is that individual genetic make up varies and as yet we have not yet found a reliable way to re engineer or repair DNA.When I was dx with CML my specialist said your DNA has been compromised but hopefully we might be able to control the damage !

Best wishes

John