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Imatinib & autoimmune condition

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Hi there, many years ago before my diagnosis of CML I was diagnosed with an autoimmune condition called angina bullosa which I now know can be an early sign of leukaemia.

I've been on Imatinib since July, in November I was told I wasn't having an optimal response and it was agreed I try a further 3 months but if still the same id need to change TKI. My review for this is next week.

Since Xmas my autoimmune condition has been significantly triggered and I'm left unsure if it's Imatinib triggering it or is a sign the leukemia is not being controlled by the Imatinib.

Has anyone else experienced something similar and if you needed to change TKI was there a better one to try?

What is the trigger? How do you know your autoimmune issue is acting up?
I was on Imatinib for 11 years. Most of what I remember of that experience is back pain.
I switched to Nilotinib and got better responses but the side effects can be more serious so beware.
That goes for most other TKIs.
Imatinib may be the least brutal of all the TKIs on the body although you wouldn’t think that from all the bone pain.

Good luck,
JP

Hiya, in all the years I've had this autoimmune condition I've never had the blisters on my body, only inside my mouth but it's escalated and I now have them on my body so thinking it can only be the Imatinib which I researched and says can trigger it or it's the leukemia not being controlled by meds as I've now learnt it could have been an early sign of leukemia and at my last review I wasn't having an optimal response as the consultant hoped.

It's such a conundrum to know what to do next so was just interested to hear if others have experienced something similar.