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PCR lab sensitivity

Is PCR reading increase from 0.022% to 0.041% in 3 months significant enough to change dosage or is it within lab variability limits?

The variability of PCR results at these low levels is easily +/- 50%. This increase is more than that, but the result is still well below 0.1%. If you have been tracking around 0.02% for a while, my inclination would be not to change now, but at your next test (when is that?) if there is a continuing upward trend in that result, then a discussion with your specialist on some change is appropriate. What TKI are you taking, at what dose?

(By the way, before I retired I ran an internationally accredited toxicology lab for some years so I know a fair bit about this stuff).

Best wishes

Alastair