I have noticed that people on Nilotanib have said they are getting an itchy rash - has anyone had a reaction on Dasatanib? I seem to have come out with a type of acne which is on my neck, chest and back. I had some antibiotics but they didn't work and I may need to see a dermatologist. Just interested to see if anyone else has had this
Karen
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Reactions on Dasatanib
I suffered from very severe diarrhoea whilst on disatinib, so after 3 weeks I was put back onto 600mg Glivec. PaulR
Thanks for your comments. I agree Michael, the tiredness is not so bad and Paul, mine has gone the other way!!!Can't go back on Glivec as i had liver problems so rather hoping that this one will work out
Karen
Hi Karen, although I am not on Dasatinib, I am back on Nilotinib following a spectacular rash! After a 10 day break I restarted at half a dosage & after a week went back up to 800mgs. This time I am taking clarityn (none drowsy & only once daily). The rash is very much improved just a bit red so maybe you could try antihistamin.
wishing you all the best.
Ali
I have been taking Dasatanib for 7 weeks now and have noticed a red rash on my chest but it does not itch.
I have been under a lot of family stress. My brother passed away on August 18. This was followed by the death of my father-in-law on October 2 , 6 weeks later. My father-in-laws's ashes were to be intered in Edinbane cemetery on the isle of Skye on 15 November. Unfortuneately on this day I suffered a stroke. At the same time - although unexplaned why it should happen - my CML escalated to the accute stage. Fortunately I am recovering from both the stroke and the leukeamia is back at the chronic stage. I am still getting treatments and hope to get a bone marrow transplant soon. I have a brother who is a 9/10 match although I think the hope is that a 10/10 match may still be found.
Dear Flora,
I am so sorry for the loss of your brother and your father in law.
I am sure that both of these awful events being so close contributed to your further health issues, especially the stroke. Having to then deal with your CML escalating is ufair to say the least.
I am so glad that you are recovering from the stoke and that you have the option of an sct to deal with your CML.
I assume that dasatinib was prescribed because imatinib (glivec) was not controling your disease? was this why you suffered a progression?
Did your doctor explain why you might be resistant to imatinib? i.e did you have a resistant mutation identified as the cause?
I do hope that you respond well to dasatinib ...as least whilst you are waiting for a 10/10 match to be identified.
The outcome of transplants depends on the donor match and your fitness levels.... amongst other things.
Where are you being treated? It is important to find a good centre that is used to doing transplants for CML. Given your other health issues (stroke) it might be good to talk to your doctor about the possibility of a RIC transplant + TKI (read my diary on the home page) as several centres in the UK are now doing this with a lot of success and it is a far safer procedure.
My very best wishes for a full recovery and continued response to dasatinib,
Sandy
Hello Sandy
This is a brief reply I will try to email you more fully later.
I am being treated at the Beatson West of Scotland Cancer Centre
There is NO medical reason for what happened to me. I was attending clinic every 6 weeks and my pcr-abl were a little bit static but going in the right derection at the last check. Professor Tessa Holyoake checked and double checked my results and found no reason that the cml should have moved one and not the way it did. My husband told me that my bone marrow was 2/3 infected at that time. I am now back to attending out patients and I am back at cml level
Today I recieved an appointment to go to the Beatson for an hour long appointment on Jan 29 to discuss the transplant - there was a large pook to read included too.
Flora