For another perspective...
I am on dasatanib. I started out on 140mg, now I am on 100mg.
When starting dasatinib I had a headache that manifested itself for a couple of hours every day. Nothing too strong. And, at any rate, it subsided in a month time, and became a general sense of tiredness (which, again, lasted only a few hours every day). This disappeared completely when I switched to 100mg.
Then there were skin rashes: many rashes when starting, especially on the calves. Now it's nothing damatic, just a few pimples, as if I had too much chocolate. Some diarrhea every now and then.
I am also quite young in CML terms (39, diagnosed at 38), but unluckily I got pleural effusion, which started last december. This might be because I was on 140mg, the probability is higher at that dosage.
Anyway, there are many degrees of PE, and mine is the mildest one. It manifested as a very small pain in the right side of the diaphragm. After an X-Ray to confirm the diagnosis, my doctor prescribed furosemide (diuretic) and prednisone. PE subsided very fast, and my predisone dosage was gradually decreased. When I stopped prednisone completely PE popped out again, so we experimented a while with dosages, and I have been taken prednisone at a very small dosage, almost homeopatic, as my doctor jokingly says: 12,5mg every 3 days, which makes for a tablet once a week, more or less.
In my last x-ray PE had disappeared completely, so I am again off prednisone. I realize this might be temporarily and it might appear again. At any rate, doctor is not worried at all, he says it's just something you have to monitor. I believe it might go away completely only with a dosage decrease, in the future.
For full disclosure at one stage I also had a small pericardial effusion, doctor said it's really the same beast so, at this level, nothing to worry about.
Of course I wish I was luckier and never had PE at all, but i's mostly a minor annoyance. It's annoying because you have to take extra tests, and sometimes extra meds, but it's completely manageable.
Apart from PE, I believe dasatinib is great. I love the fact that it has no food interaction (apart from the infamous grapefruit juices & co), that you have no nausea, no fasting required, etc.
A couple of days ago I was travelling and had to have lunch on the go. I decided to treat myself with some trash food once in while, so I had a slice of pizza and a coke. It was dasatinib time, so I gulped it down, with the coke. While doing that I thought, well, not the most orthodox practice, but the fact I can do this is quite good.
Best of luck!
Davide