I thought I'd see what people's thoughts are on this paper I recently read:
"Defining therapy goals for major molecular remission in chronic myeloid leukemia: results of the randomized CML Study IV"
It seems to conclude that if you have not achieved MMR by 30 months, but still remain under 1%, than your overall outcome is not as good as MMR? Suggesting at 30 months if you are between MMR and CCYR you should switch medications. This seems to disagree with the recent NCCN guidelines and opinons I have received from a CML specialist. I am currently at approximately 30 months and between MMR and CCYR so this is a very relevant topic for me as I consider pushing my oncologist harder to switch medications from Sprycel. I don't understand how the hazard ratio is calculated in this paper, which seems to be the parameter used for this conclusion. I also don't understand whether the differences in hazard ratio are significant between reaching MMR and CCYR at 30 months. I'm hoping someone can shed some light on this topic. Thank you.