I preface this by saying no judgement please. Do you all respect the posology prescribed by your physician. Did some of you actually decide to avoid the hassle of arguing with your doctors and just lower your dosage. I stumbled on this article that concluded with a study on drugs in general and a CMLer that achieved Undetectable and even attempted TFR with ridiculously low dosage that CMLers just didn't respect their prescriptions and lied about it and therefore the standard treatment that we think is working is actually overtreatment. Is this true? I got to say I rolled my eyes reading this simply because the premises for their arguments are simply too thin. However I gotta say that knowing the freedom of the american spirit I can believe it (this article is from the US). Maybe a regional phenomenon ... Also it wasn't long ago that 800mg of imatinib was the recommended dosage, dose ranging CML medication on so small a population must be a tall task . So do you respect your dosage? and if you don't is it intentional? If not why? Thanks!!
This is the quote from the article:
"A study about medication adherence showed that, in general, 18.9% of drugs that were considered to be important by physicians were actually being used incorrectly by patients, and that patient nonadherence was intentional approximately 50% of the time."
"Therefore, we believe that a significant number of patients with CML may actually be using lower doses of tyrosine kinase inhibitors than their physicians assume, because of side effects or the patients’ desire to maintain the relationship with their physician."