"Berberine" brings up no results in searching this site.
It is unusual that a simple supplement might degrade BCR-ABL. The following may be interesting (BBR stands for Berberine):
"The results show that BBR directly binds to and degrades BCR-ABL and BCR-ABL T315I via the autophagic lysosome pathway by recruiting LRSAM1. The use of BBR is a new strategy to improve the treatment of patients with CML with imatinib sensitivity or resistance."
Hi Nimbus
Thanks for this which is interesting.
It appears to be a plant based extract and which is sometimes used to regularise blood sugar levels and to reduce cholesterol levels and is anti inflammatory. I see that the capsules are available on Amazon.
I general terms I think that it is very worthwhile to consider some of the possible benefits of plant based extracts and a diet high in phyto chemicals.-flavenoids and polyphenols found in many fruits, vegetables and nuts A good read on this is the book by Robert Thomas a qualified oncologist on "Lifesyle after Cancer". Perhaps current research work on so called superfoods is not just fad or peripheral science?
Regards
John
Thank you, John.
Two plants were delivered into my garden by birds. The plants looks rather like holly but the leaf is yellow and the fruit is black. It turns out to be Oregon grape, plant in the family Berberidaceae.
The second authority is part of a masters degree dissertation written by student microbiologist in China and this alone may not be of great value. The first authority is up-to-date and rather more interesting because it appears that a natural substance could be useful for overcoming imatinib resistance.
There may just be some good science written around these texts.
Hi everyone
Thanks for two worthwhile reads.
This is all very interesting and the first time I've ever heard of Berberine. I did some research on it and found it is sold as a supplement here in South Africa too, very cheap from our large chemist chains.
I'm always scared to try any changes as I recently lost MR4 and am worried about my response. However, I'd be very interested to know if anyone has any success with this.
I also see that it seems to be a CYP3A4 inhibitor like grapefruit. In other words, taking it might lead to increased concentrations of the TKIs in our blood... so maybe it enhances the effectiveness of the drugs like that? I have often wondered whether eating a wedge of grapefruit might improve my response as more drug would be absorbed... but terrified to try this!
Best of luck everyone.
Martin
An article appears here: 4 Natural Supplements That Are as Powerful as Drugs
https://www.healthline.com/nutrition/4-supplements-as-powerful-as-drugs#...
The list is:
berberine
curcumin
red yeast rice
garlic.
I have self experimented with berberine and I am waiting to collect all relevant blood result. Notably, I appear to have overcome my TKI resistance by moving down one log.
Thank you, Christine.
I was a little disappointed with the webinar. It was a panel only discussion with no real opportunity for patients to interact. Leukaemia UK is not so good at collecting together the questions that have been submitted in advance. Nonetheless, the commentary concerning ASCIMINIB was encouraging.
Yes, it does appear that the panel considers that there are no longer term side effects of taking TKIs. I do wonder though whether more ailments are discovered in patients who are under long-term supervision. I had a CT scan (following on from an x-ray in January) today for my lungs (not apparently pleural effusion) and I do not even have symptoms of a lung issue.
