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Berberine

"Berberine" brings up no results in searching this site.

It is unusual that a simple supplement might degrade BCR-ABL. The following may be interesting (BBR stands for Berberine):

"The results show that BBR directly binds to and degrades BCR-ABL and BCR-ABL T315I via the autophagic lysosome pathway by recruiting LRSAM1. The use of BBR is a new strategy to improve the treatment of patients with CML with imatinib sensitivity or resistance."

https://clincancerres.aacrjournals.org/content/26/15/4040

Hi Nimbus

Thanks for this which is interesting.

It appears to be a plant based extract and which is sometimes used to regularise blood sugar levels and to reduce cholesterol levels and is anti inflammatory. I see that the capsules are available on Amazon.

I general terms I think that it is very worthwhile to consider  some of the possible benefits of plant based extracts and a diet high in phyto chemicals.-flavenoids and polyphenols found in many fruits, vegetables and nuts A good read on this is the book by Robert Thomas a qualified oncologist on "Lifesyle  after Cancer". Perhaps current  research  work on so called superfoods is not just fad or peripheral science?                                                                                                                                                                                                

Regards

John

Thank you, John.

Two plants were delivered into my garden by birds. The plants looks rather like holly but the leaf is yellow and the fruit is black. It turns out to be Oregon grape, plant in the family Berberidaceae.

The second authority is part of a masters degree dissertation written by student microbiologist in China and this alone may not be of great value. The first authority is up-to-date and rather more interesting because it appears that a natural substance could be useful for overcoming imatinib resistance.

There may just be some good science written around these texts.

Hi everyone

Thanks for two worthwhile reads.

This is all very interesting and the first time I've ever heard of Berberine. I did some research on it and found it is sold as a supplement here in South Africa too, very cheap from our large chemist chains.

I'm always scared to try any changes as I recently lost MR4 and am worried about my response. However, I'd be very interested to know if anyone has any success with this.

I also see that it seems to be a CYP3A4 inhibitor like grapefruit. In other words, taking it might lead to increased concentrations of the TKIs in our blood... so maybe it enhances the effectiveness of the drugs like that? I have often wondered whether eating a wedge of grapefruit might improve my response as more drug would be absorbed... but terrified to try this!

Best of luck everyone.

Martin

An article appears here: 4 Natural Supplements That Are as Powerful as Drugs 

https://www.healthline.com/nutrition/4-supplements-as-powerful-as-drugs#...

The list is:

berberine

curcumin

red yeast rice

garlic.

 

I have self experimented with berberine and I am waiting to collect all relevant blood result. Notably, I appear to have overcome my TKI resistance by moving down one log.

Just saw a webinar where a specialist said research is on going into Berberine but it would appear the volume needed to have any benefit makes it an impractical option.  

Sounds like it was a good idea to ask it. I found it very interesting.

I asked the question about the long term side effects of TKIs. Interesting that they thought there weren't any for most TKIs.