"Berberine" brings up no results in searching this site.
It is unusual that a simple supplement might degrade BCR-ABL. The following may be interesting (BBR stands for Berberine):
"The results show that BBR directly binds to and degrades BCR-ABL and BCR-ABL T315I via the autophagic lysosome pathway by recruiting LRSAM1. The use of BBR is a new strategy to improve the treatment of patients with CML with imatinib sensitivity or resistance."