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E450K Mutation

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Hi all.

Are any of you familiar with the E450K mutation? My doctor tells me it is known for causing other mutations, but that's all the info I have.

I was on Imatinib for a year then it stopped working (which was when the mutation test was taken), then Dasatinib for 6 months but had to stop it as one of my lungs filled up with fluid - it was working well too but the side affects were bad, and now on Nilotinib which I'm handling ok so far at least.

The mutation test took about 6 months to come back so only finding about this now. I tried Google but there isn't much information out there at all.

I would appreciate any info anyone has.

Thanks :)

I found this:  https://pubmed.ncbi.nlm.nih.gov/19768693/

From a cursory look it appears that some mutations transform to T315I.  So maybe ponatinib or asciminib would be something to consider.

▼https://communityview.lls.org/statuses/8604
  Trey

The E450K mutation can come and go, but it is NOT a precursor to other mutations.  It is a mutation which can be transient, which is not unusual.  I would suggest a re-do of the mutation test.  E450K is not considered to be a difficult mutation to overcome if it does persist, which it may not.  But if it persists then Ponatinib may be the preferred TKI.

Thanks I appreciate the link.

Thanks for posting over there. I will reply there was well. It will be interesting to see if there is any publicly available info.