Hi Everyone,
I was wondering if any one of you have experience with failed TFR? How long it usually takes for dasatinib to start working again?
I was on 50mg of dasatinib and undetectable for almost 2 years, but i developed some rhabdomyolisys and my haematologist suggested it may be related to TKI so i ended up stopping all TKIs and got hospitalized. My rhabdo cleared up in about 2 weeks nicely, but it certainly was no joke. Both my arms swell up like a Michelin doll, and i put on about 8kg of water weight with the swelling and inflamation.
After about a month without TKI my first pcr test came back with detectable brc-abl, around MR4 (0.0107). At this point we restarted 50mg dasatinib and tested again 2 weeks later, which showed a rather large growth of almost a full log to 0.085. I am a bit worried at this point… that is very close to losing MMR.
Do you think 2 weeks may not be long time enough for dasatinib to kick in? The growth rate is a bit alarming (logarithmically speaking). From ND to the edge of MMR in less than 2 month? I have heard some anecdotes claiming that younger people may get more aggressive response, and i’m 35. But still…
Is there anybody with TKI restart experience? I hope this episode didn’t completely wipe out that ~4 years of treatment progress that took me to get here.
Thanks in advance!
—Thomas