You are here

Third or booster Covid jab for "vunerable" patients in UK

Categories:

Hi All in UK,

I see that those having leukaemia will be included in the group who will be offered a third jab.There is some confusion as to how the list will be compiled-for instance will it refer back to the database of those deemed to have needed to shield at the time of previous lockdowns or will a new list be compiled by GPs and/or specialists.This time it appears not to be totally age related as it will include younger people with immune suppressive conditions or treatments .I have read that Pfizer or Moderna will be used for the third vaccination.

Has anyone found or read how it will operate?

Regards

John

Hi John. BBC article on this here.

It includes the phrase

"Those eligible for a third dose include people:

  •     being treated for acute or chronic leukaemia at the time of vaccination"

This implies that all CML patients will be included. I hope that my situation where my consultant is in England but my GP is in Wales does not complicate the decision making again.

The link i found on the BBC to the gov.uk website says it will be specialist lead but other articles say it will be a letter from your gp within 10 days.

JCVI meeting minutes are published here, but there's nothing very recent up yet. But likely to be a good place to get info from the horses mouth.

https://app.box.com/s/iddfb4ppwkmtjusir2tc

I have just seen a report on Medscape dated September 1 st and I summarise:

Jonathan Van Tam said "I welcome the advice from JCVI to offer a third primary dose to those with severe immunosuppression, at a bespoke interval advised by their specialist clinician,and guided by the UKs  immunisation handbook ,the Green Book"

Certain groups will be offered other medical interventions that can be used in these groups including specific treatments like antivirals and monoclinal antibodies.A flexible approach given by JCVI was to have the third dose before starting chemotherapy rather than during treatment.

Severely immunosuppressed people would still be likely to to be offered a booster dose some weeks after their third dose.

So as far as us CML patients are concerned one of the key issues is whether we fall into the category of being severely immunosuppressed as a result of our tki treatment that essentially is targeted molecular therapy rather than being specific and cyclic chemotherapy infusions .My specialist sometime ago was of the opinion that we with CML might be mildly immunosuppressed only.

As well in the absence of data that would indicate as a group (CML) our antibody status after two doses is different from the general population  then we might still be wondering whether it would be wise or necessary to have the booster dose following the third dose (it looks likely that the so called booster dose would be offered to a wider audience based on age such as over 50/60 and a range of other conditions and we await government announcement on this).

Has anyone come across any definitive studies of the antibody response after two jabs for CML patients as a group as opposed to leukaemia patients in general,or the wider group of blood cancers,or the broad group cancer sufferers? In other words what is our immune response.

Next week I have a face to face with my specialist  who holds a senior position at a major London cancer treatment hospital  and I will  try to find out a little more on this issue and seek his opinion.

Regards

John

https://bloodcancer.org.uk/news/why-am-i-being-invited-for-a-third-covid...

I know originally it seemed that cml patients were assumed to have a response similar to a healthy person but i am not sure the theory matches reality.  I had a test after my 2nd dose and know that i have less than half the anti bodies produced by a healthy person.  I think others have been told the same.  Little research appears to have been on cml patients. 

Hi Christine,

Do you consider yourself to be severely immunocompromised? If so, then it might be a good idea to talk with your clinician about whether you should be offered a 3rd vaccine, if you want it. 

Professor Jonathan Van Tam, England's deputy chief medical officer, said in response to the JCVI's recommendation: "I welcome the advice from JCVI to offer a third primary dose to those with severe immunosuppression, at a bespoke interval, advised by their specialist clinician, and guided by the UK’s immunisation handbook, the Green Book. (my highlights in bold)

He also said:

"We should be doing all we reasonably can to ensure that this group is not disadvantaged and a third primary dose is one step in this direction. We are also working hard to ensure there are other medical interventions that can be used in these groups, including specific treatments like antivirals and monoclonal antibodies."

I assume the monoclonal antibody he is referring to (the drug that Trump was treated with) has now been approved by FDA etc. - Ronapreve/Regeneron.

In general, I CML expert clinicians do not consider CML patients treated successfully with TKIs to be severely immunocompromised. However, there are always exceptions.

Sandy

JCVI specifically state Cronic and Acute leukeamia should be vaccinated and my consultant has already said i need another vaccine as she did an antibody test and my response was not good. The third jab is done to make the response equivalent to a healthy person and mine is definitely much lower than that. I am sure not every one will have this response but there is i do not know any reason why my response should  be impaired. I am 57 with a pcr of .02 so well managed.

May be I am the exception that proves the rule and everyone else has the same response as a healthy person and will not need it. 

May be I am just looking for a way to re-join everyone  else and stop being petrified   .  I would love to have some independence back and to be able to get on public transport and may be even sit inside in a restaurant or coffee shop.  I have been told to remain being very careful so my only hope is a 3rd dose. Clinging to hope.  

I agree with Christine,  I had an antibody test done by hospital when having last routine  blood test and although my Haematologist was pleased that I had produced some antibody response I was told it was insufficient and not the equivalent of that expected from a normal healthy adult so to "continue to be careful" tricky  teaching in a uni situation however she did say that she hoped a third or booster would become available and although she would not put CML patients at the head of the queue she hoped that we would be considered eligible before the general roll out to all over 65s.

Christine - do you know your vitamin D blood level?

I had a blood test a few years ago and was told it was slightly low. I was seeing a nutritionist at the time who advised i take 4,000 iu daily which i do. Not had it tested since as it is not a test that is done routinely. I will ask for it to be added to my next tests.

Just found the result. Was 40 and i was told to take 1,000 IU per raise of 10 which is why i take 4,000.

Christine - You want to increase your D level to over 50 ng/ml ideally around 70 ng/ml. for maximum benefit against respiratory virus' as well as help minimize cancer.

I take 7500 IU's per day in Fall/Winter which for my latitude is now. I do this by taking 5,000 Iu's one day and 10,000 the next.

This barely keeps me close to 70 ng/ml - although it has fallen as low as 50 even on this dose during winter. I take it with vitamin K2 (200 mcg) as well.

Thanks Scuba. I will try to get it checked shortly as i am due a blood test in the next couple of weeks.  I do spend a lot of time walking but in winter the sun does not shine much in the uk.  As vitamin D is more in the news these days i wonder if they will keep more of an eye on it. None of my consultants have really been that bothered and one said just to take the standard 1,000 IU.

Hi Christine

If as you say JCVI have stated that CML and AML will be included as conditions that  fall under severe immunosuppression then I guess that all of us with CML will at some stage be qualified to take up the offer of a third dose.From what I have read when the booster jab programme is announced for over 65 s then we would be asked to take another jab as well under the  .

I dont know my antibody status but I will seek to have the test if possible .I do know how you feel about being reticent to go back to normal-back in Nov 2019 I had to discontinue imatinib due radiation therapy for prostate cancer  but after 14 weeks lost my MMR and slipped back to a PCR of 10%! It took 14 months to get back to a PCR below 0.1 which is safe territory.

Despite not knowing my antibody status I decided 3 months ago to try to go back to normal by going to the shops, supermarkets and restaurants but to still take the precautions;I have noticed  though a fairly rapid decline  by others in the use of masks and also sanitising which does concern me.

What is not being publicised are the spikes in cases post festivals among the young and how in Devon and Cornwall post so called staycations the young and the unvaccinated are very prone to contract still quite serious cases of Covid.

As a postscript some recent research from Israel has shown that booster jabs have started to have an impact on lowering recent spikes in even double vaccinated people (general population).

I am quite happy to have two more jabs  for extra protection if and when available.

Also dont forget the flu jab which is available with Boots (my preference) free of charge late September early October  and some well organised GPs.

Regards

John

Hello John

I raised a question with Blood Cancer UK but did not get an answer:

 

The [Blood Cancer UK] article states "This will largely be managed by GP surgeries, however specialist input will be required for people who are currently receiving treatment to ensure the third dose is given at the most appropriate point in someone’s treatment cycle."
How will this work? Presumably, the GP surgery looks for codes in its patent database to find patients with applicable conditions. Then how does the GP ascertain which patients are currently receiving treatment? Then to get specialist input, does the GP write to each and every specialist to request advice in respect of each and every patient? How long will the process take for the GPs and the specialists to complete this process?
I have CML and would fall within the first bullet point of Group 1. The nature of CML is that nearly all patients will be receiving treatment. The note would indicate that a correspondence trail is necessary before anything happens. What are the indicative timescales for this process? Could it take weeks?

 

Blood Cancer UK also published the following in respect of CML:

"we know that some people with chronic myeloid leukaemia tend to have a better response to the vaccine than some people with chronic lymphocytic leukaemia. However, even in people who do develop antibodies the quantity of antibodies produced tends to be lower in some people with blood cancer, compared to people who are healthy, and we don’t know how well those antibodies function. We also don’t know how long antibodies last in the blood and it’s likely their numbers decrease over time and it’s hoped that an additional dose will increase the response in some people. So, even if you developed antibodies after two vaccine doses, it’s important you still get your third."

 

I read the above as advising that people with CML must take the third vaccine.

 

Personally, I am still taking great care. I do go swimming but I am very careful with cleaning, mask wearing etc. I use lateral flow tests twice weekly.

 

Hi Nimbus

Your comments are  interesting on a number of counts.

A Perhaps it is an idea for us with CML to ascertain our antibody status so that if we  have a depleted status we can really push to be jabbed for the third time.

B.It is still unclear as to who will make decisions as to who will qualify-1. GPs,2. GPs/specialists or 3. specialists alone;if you remember at the beginning of Covid the database compilation of vulnerable persons was flawed and chaotic.I see my specialist Tuesday so will ask what is going to happen.

C. I have just seen a gastro-enterterologist who said the third wave is on the way and with many of the population not aware or not caring and with the return to Universities and schools we are going to have an explosion of numbers but with a hospitalisation rate lower than previous waves.However there will be impacts on procedures so for instance if one needs a scan it has to be deemed urgent and if you need a colonoscopy say then because of the risk of Covid it has to be deemed very urgent -that is even in the private healthcare sector. In the NHS the wait might be months or years I guess.

Blood tesst are being rationed because we are short of containers and now the flu jab roll out is delayed for two weeks due to distributional problems over lack of drivers!

So I think we need to establish to what extent we are at risk-ask for an antibody test or pay for one privately and then push by whatever means to be third jabbed.

I think in the next week or so government will push for children 12 plus to be vaccinated and boosters for over 65 s announced -this is apart from the third jab for the immunosuppressed.I dont think we will have any more lockdowns nor will we have any more compulsory masking or sanitising so the risks for the vulnerable will be heightened and it will the survival of the fittest in order to reach that awful term herd immunity .Take care.

Regards

John

Hi Christine,

In some countries, including UK, vitamin D levels are measured using units called nanomoles per litre or nmol/L.

In the US and a handful of other countries, levels are measured using nanograms per millilitre or ng/mL. The two differing units of measurement are much like metric vs imperial and this can lead to confusion about the results.

So you can see that knowing which unit of measurement your result is measured in - ng/mL or nmol/L -  is important,  so your level at 40 nmol/L is extremely low and would be the equivalent of <25 ng/ml which is definitely sub-optimal and some would say, deficient. 

To convert ng/ml (US measure) to nmol/L (UK measure) multiply the ng/ml by 2.5 for example 50 ng/ml = 125 nmol/L. So you would really want to get your level up to at least 125 nmol/L (UK)

If you can increase your dose to at least 8,000 iu per day, say for around 2-3 weeks, then retest you should see a boost in your level and you can take it from there. 

I really understand why you want to re-gain some confidence so you are able to do 'ordinary' things without overly worrying about your immune response to infections such as Covid or even Flu and other respiratory illnesses. Boosting your D3 level should give you some confidence. 

Best wishes,

Sandy

 

 

 

Thanks Sandy.  The results say 40 nmol/L with a normal scale of 50 to 174.  My haematologist didn't seem too worried and said it was slightly low but the nutritionist was more concerned.  I have 4,000 IU tablets and have ordered some with 4,000 but with K2 as i intend to take one of each per day.  The only place i can find anything over 1,000 IU is Amazon as pharmacy's and health food stores don't seem to do it.

I don't find it easy to get the Vitamin D tested and with the current restrictions due to the lack of tubes this may be difficult for a while yet.

 

I phoned my gp surgery yesterday to book my flu jab and asked about the 3rd jab and was advised that they had no information about it as yet and didn't know how it would work.

Dear Sandy

As far as I can see Vitamin D does not appear on the standard blood tests list and does not appear to be a subset of another test.

What are the circumstances in which NHS clinicians will order a Vitamin D test?

Regards, Stephen

 

Hi Stephen,

If you ask your consultant specifically I am sure they can arrange a test. I was tested at HH, but that may be because I am a post transplant patient (2003) and I think they do extra tests to check for possible longterm effects from transplant. However, it may be that HH are more rigorous in their monitoring? 

You can buy D3 tests online from UK labs that NHS uses, but why pay if your clinician is willing to test you. Optimal D3 is crucial to overall health including protection from serious effects of Covid infection (increasing amount of data). UK clinicians tend to be conservative when assessing optimal levels of D3, best to do your own research on that, which I am sure you are aware of.

Sandy 

Hi Christine,

I order 4000 iu with correct amount of K2 included ... as you have found high dose caps/tabs are more readily available from amazon. (if you do order via amazon please use smile.amazon and choose the chronic myeloid leukaemia support group as your preferred charity - (this means we will get a small percentage of your purchases donated to us - every little helps us keep this website going!) 

Sandy

Hi Christine,

I asked my consultant a few days ago when we had a face to face how the third jab would work and he said specialists and hospitals have responded to government that they do not have the resources to develop this data base and to administer it so over to GPs!

I suspect GPs will say it is not their job.

I have read that plans for the booster for age 60/65 will be announced soon so there is lots of mixed messaging and prevarication from Department for Health.

Regards

John 

Hi John

Everything went silent and the vaccine minister then added us to the first people to get the booster so i assumed it had all be abandoned. Then yesterday and this morning I saw a number of nhs trusts had posted on twitter to say that people would be contacted shortly and not to contact the nhs.  There was also an online article from "Pulse" saying vaccines could begin on 13 September as the nhs systems needed to be amended to allow for the inclusion of a 3rd jab.  GPs were given to the 17th to finalise the list.

To be honest i have no confidence in being contacted so it is still just a wait and see.  All seems a complete mess. 

I had a text message from my GP last month saying I'd be getting the booster jab (and flu jab) and they'd be in touch.  Speaking to my GP this week and they are hoping to have the jab available for their flu clinic on 25th September, but as yet they have no further inforamtion from the Government so it's not a definite date.

More important than getting the vaccine or booster shots is making sure your vitamin D level is higher than 50-55 ng/ml. Having a high vitamin D level BEFORE you are exposed to Covid will insure you either do not get sick or it is mild and not an issue.

Remember - it can take many weeks to raise low vitamin D levels. During this time, Covid is a risk - vaccinated or not. But once your vitamin D levels are higher than 55 ng/ml - and you become exposed to Covid, chances are you won't even know it.

Just had a reply on twitter from one of the doctors on tv to say letters will go out on monday from gp's and hospitals

.... what is going out in letters from gp's and hospitals?

Hi Scuba,

As I read it the third dose is planned to be given to those deemed to be severely immuno-suppressed which includes those patients with CML and government has indicated that either specialists/hospitals and/or GPs have the responsibility to develop a database of qualifying patients who will be contacted to confirm their eligibility for a fairly immediate additional vaccination and outlining the arrangements for administration-presumably either through the NHS or via third parties (Accurex or similar) under contract to government/NHS as per the roll outs of the first two doses.Doses will commence very soon.

The third dose will be targeted to a specific audience whereas the booster jab will be offered to a broader base based on age of those over 60/65.Leaving aside semantics it seems that third dose is different from boosters and the immuno-suppressed will after the third dose still qualify for the booster at a later date.

I read an article in Telegraph online which indicated the following.Dr Fauci said that third shots (for the general population) should be a standard regimen for Covid 19 jabs. Dr Taureci  ( partner to Dr Sahim who developed the Pfizer jab) said in the book "The Vaccine" by Joe Miller that if the aim is to reduce infection then boosters might be used earlier but if on the other hand it is to reduce severe disease and hospitalisations then booster shots should be done much later.Sarah Gilbert at Oxford said bossters for the developed world are less of a need than vaccinating the rest of the world;similar to WHO sentiments.

"The Vaccine" is being launched this week .Some interesting information in the book suggests that Pfizer at first rejected the approach from Drs Sahim/Tureci and their start up bio tech company and did not see a commercial need for a vaccine back in January 2020-previous SARS and MERS outbreaks had resolved themselves prior to any vaccine being developed.After the Wuhan lockdown and the emergence of symptom free transmitters being discovered, Pfizer rapidly changed their minds.

The whole episode of the development of the Covid vaccines reads as a war of commercial interests/trade blocs and governments.Some unidentified lobbyists to EU in Brussels wanted the Commission to drop/block  the Pfizer vaccine because it was priced high at over £29 per two jabs and would lead to undue transfer of wealth to USA! EU then rubbished Astra Zenica and Macron being particularily vindictive to offer non medical opinion to denigrate the efficacy of the Oxford based product.The Pasteur institute in Paris failed in their attempts to develop a vaccine.  Australia failed in its homegrown efforts to develop vaccines and subsequently turned its population against using Astra/Zenica. Italy physically blocked an export of Pfizer to Australia and EU wanted to block exports of Pfizer vaccines to UK  from German processing plants-all went quiet when UK pointed out that one plant in Yorkshire made all of one of the vital components of the vaccine and manufacturing supply chains were complicated and across borders.

USA has still not approved use of the Astra Zenica vaccine.

In the absence of data on the antibody response of CML patients we are still in the dark re the need to have the third dose (and then subsequently a booster as well).

I will take all that is on offer and am on track for a flu jab in a few weeks time as well.

Best wishes,

John

If you look online most countries have started the additional jab on immunosuppressed. As far as i can see the USA has been doing it for some time and so has a lot of Europe. It has been agreed we should have it but the system has not been put in place yet.

I agree there are still alot of unknowns. Are we more at risk if we get covid and what proportion of cml patients have a strong response to the vaccine? It us a shame little practical research has been done on this and most is theory.

If you look online most countries have started the additional jab on immunosuppressed. As far as i can see the USA has been doing it for some time and so has a lot of Europe. It has been agreed we should have it but the system has not been put in place yet.

I agree there are still alot of unknowns. Are we more at risk if we get covid and what proportion of cml patients have a strong response to the vaccine? It us a shame little practical research has been done on this and most is theory.

Hi Sandy

On the subject of vitamin D, I had mine retested last week after being of 4,000 iu for the last 2 years since i was told my level was slightly low at 40nmol.  Normal is 50 to 175.  My result for last week is 178 nmol so it is too high now and I have been advised to reduce my supplement level.  This obviously shows are bodies each react to vitamin D in a different way so level of supplements need to be checked with blood tests. I was told a high level can result in calcification.

Interestingly my haematologist wasn't a fan of vitamin D supplements and is an unbeliever in the benefits.

He also told me he had no anti bodies from his vaccine but caught covid which had minimal impact for the week he was positive.  He believed T cells were much more important.

I know we all have different opinions and are bodies all react differently but this has given me a bit of courage that i may be more protected than i first thought.     

Hi, do you not take vitamin  k2 with your vitamin D3 as they work together ,this should help so you can't overdose .

I'm sure Sandy will reply to your post.

Your 178 nmol is PERFECT. In fact, Sandy will likely say it is a bit low.

Your hematologist doesn't have to be a fan of vitamin D supplements. You do! You should ask your hematologist what is the role of vitamin D and vitamin K2 in the caroboxylation reactions in calcium transport. If he doesn't know - get a new hematologist.

So called 'normal' vitamin D levels are set by so-called 'experts' in order to prevent rickets. This is what the normal range is referring. Vitamin D, however, is vital to immune activation of T-cells. The very cells your hematologist mentioned. He probably doesn't know vitamin D's role in T-cell activation.

To repeat:

1. Vaccine triggers an antibody response forming an antigen to the viral protein. In order to attack the virus (or the vaccine itself), T-cells have to be activated (replicate in large numbers). During vaccine response, few T-cells are made because the vaccine is finite. Only the antigen remains as part of the immune memory ready to form T-cells specific to the virus.

2. When the virus is encountered again, T-cells take up vitamin D (via their vitamin D receptors) in order to replicate in large numbers and attack the virus. This replication is what leads to a large antibody response. Without adequate vitamin D - T-cell response is sluggish taking days what otherwise would take a few hours.

3. Studies have shown that maximum T-cell response occurs when vitamin D level is greater than 137 nmol/L. And maximum cancer suppression response is documented at greater than 70 ng/ml. This is why it is important to maintain vitamin D levels at or greater than 70 ng/ml for CML.

So-called over calcification due to high vitamin D is near impossible below levels of 500 nmol/L - and if you take vitamin K2 with your vitamin D3 and keep daily vitamin D3 intake to no greater than 10,000 IU's per day - it simply won't happen.

 

 

I have an appointment next week to take a sample for BCR-ABL, with a view to going back down to 200mg imatinib. I have asked for Vitamin D and covid antibodies to be checked at the same time. The haematologist has agreed to the Vit D, on the basis that he can't prescribe if it is too low, but says the hospital can't do the covid antibody test. I have asked my GP surgery if they will do the antibody test but have not had a reply.   

Hi Christine,

I agree with everything Scuba has noted in his post to you. I would like to point out that the difference in measurement of D3 is crucial when trying to follow the 'guidelines', which Scuba also pointed out is the lowest level you can have before risking development of rickets!

From what I understand 40 mol/L(nmol per litre)  is not 'slightly' low, it is according to some research, very likely verging on deficiency. Your result from last week at 178 nmol per litre -again from what I have read - is not considered by some to be 'too high' at all and certainly does not put you at risk of toxicity! 

To convert nmol/L (your measurement) to ng/ml divide by 2.5.

So your D3 level is currently at 175 nmol/L divide that by 2.5 and your result is 70 ng/ml, which to many researchers or forward thinking doctors on this subject, is a good level, if not yet at optimal.

It depends who your read/listen to. Scaring people with possible D3 toxicity is to my mind irresponsible without giving the context of what toxic levels are. Toxicity is very rare and difficult to achieve...see another post I made on a different thread. 

-----------------------------------------

Snip from another thread -

It is highly unlikely that you will 'overdose' ... D3 toxicity is extremely rare and would mean taking excessive amounts over a very long period. For the worried/cautious amongst us, please see this publication, by Michael F. Holick, PhD, MD, Section of Endocrinology, Diabetes and Nutrition Department of Medicine Boston University Medical Center Boston, MA, which discusses the topic of D3 toxicity.

".......The evidence is clear that vitamin D toxicity is one of the rarest medical conditions and is typically due to intentional or inadvertent intake of extremely high doses of vitamin D (usually in the range of >50,000-100,000 IU/d for months to years...."

------------------------------------------

Why convert your measurement? Because most of the research that I have read on optimal levels (not medically conservative 'status quo' levels) uses ng/ml which is a much small amount of plasma -per millilitre instead of per Litre. Here lies confusion and the apparent cautious (scared for no reason) attitude of some members of the medical profession who are not expert or even basically educated in nutrition and or vit/min supplementation.

It is entirely up to you who you listen to.

My own choice is to keep my D3 levels at or above 100ng/ml (which is equal to 250 nmol/L) I do this by reading not only as much as I can on the subject of optimal nutrition, but by also 'listening' to my body and then making my own decisions. I feel better on so many levels when I keep D3 at an optimal level for myself as an individual. Age, weight and general health can effect what works best for any individual. 

It is your choice, but my advice is to keep your level well above the current minimum recommendations. So your current 175 mol/L is much better than your previous low level.  Read as much as you can and make your own decisions.

Sandy

Funny how different hospitals do things so differently. My doctor is happily running a quantitative antibody test for me, but it comes with big warnings on how to interpret it.

If you just want a quantitative one they are fairly easy to arrange. I did one through the ZOE COVID study.

David.

Additional recent information that vitamin D will help minimize Covid severity or outright prevent it.

Vitamin D may protect severe Covid infection, death: Study
September 16, 2021

LONDON, Sept 16 : Good amount of Vitamin D in the body before Covid-19 infection can prevent severe disease and death, according to an international study.

"They found that being deficient in vitamin D before contracting Covid-19 has a direct impact on the disease’s severity and mortality."

 

The linked article's conclusion should be no surprise to readers of this forum. I will be more blunt:

The single most important thing you can do to protect yourself from Covid - more so than the vaccines - is to get your blood vitamin D level above 55 ng/ml by supplementing with vitamin D3.

I am so convinced of this by my own personal experience over 10 years as well as all of the emerging research that I have zero personal fear of contracting Covid. I am sure I have been exposed to Covid from friends and family who all have had Covid (despite vaccination!) and called me (contact tracing) to warn me. Days and days later - nothing. Years later before Covid and exposed to people with colds and flu - nothing. Not even a sneeze.

Vitamin D is not magic. It simply is needed by the body acting like a hormone in sufficient amount to activate T-cells. These T-cells attack respiratory virus' and THEN (and this is important) other vitamin D activated T-cells are needed to calm the inflammation response against the virus AFTER the virus is gone. Recall people in the hospital on ventilators are there long after the virus is gone and the cytokine storm is wrecking havoc on their lungs. This is what kills in Covid (hypoxia). Vitamin D helps prevent the cytokine storm (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246956/) so recovery is quick.

Other supplements which work with vitamin D to help it do its job include zinc, quercetin, and vitamin C. But without adequate vitamin D levels, other nutritional support is secondary.

Get your vitamin D level tested. Know your number (in nmol/L or ng/ml) and then supplement sufficiently to raise your D level to be above 55 ng/ml. Also note that it takes weeks to raise your D level. The time to do this is long before you are exposed to Covid. Start now if you have not done so already. Avoid taking more than 10,000 IU"s vitamin D3 per day. I take 7500 per day currently - and that barely keeps me at 70 ng/ml.

And as a bonus - you will be fighting CML too!

 

Interesting info Scuba.  Why do you think Haematologists are not so interested in Vit D levels?  Mine said a test was unnecessary if I was eating a normal balanced diet and wasn't incarcerated out of daylight so my vit D levels were never checked until I changed GP who added it on to my blood form and I discovered it was pretty low (25) so I am now taking the weekly high dose supplements and then going on to a maintenance dose.  If it truly has a key role in fighting infection then knowing a patient like me  hasn't had a particularly good response tot he vaccine you would think they'd be encouraging us to ensure good vit d levels also.