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My high platelet

For the past 10 months I have been experiencing very platelet from 400 to 1,500,000 . …I was placed  on hydroxyurea to fight it and the beginning was relieving….I thought I had finally gotten control of it only to find out subsequent months that it not going to get to normal level soon. After the first 3 weeks of my treatment my platelet went down to 450-500 only to discover later that it had gone up to 920 then 1,200,000 . Presently it’s 820 . 
my everyday hydroxyurea dose is 1000mg . Allopurinol 300mg and a blood thinner aspirin of 75mg. 

My doctor suggested I do a mutation analysis test and the result came out positive (mutant). Initially I was on 400mg of imatinib and was placed on 600mg because of the high platelet. 

please Ai need your advice because I don’t know what to do anymore. My doctor suggested that I will have to change medication. 

Just for clarity you’ve been on Hydroxy for 10 months did I read that right? If so seems an awfully long time. I had high platelets of about 900 when diagnosed and wbc of 330. I was on high dose hydroxy for 3 weeks my counts were initially stubborn. White cell fell to 14 and platelets remained high at about 500. As soon as I started TKI and almost 5 years later they’re all perfect.

Couple of questions how long have you been on Imatinib as it’s not clear?

And what mutation do you have? Having a mutation isn’t necessarily a problem as TKIs target certain ones. And the T3151 is also treated now with a couple of TKIs. There are some unknown ones but they remain very rare.

All the best

Alex

I did a JAK2 V617F Mutation. 
I have been on Imatinib for 8 years now and yes I have been on Hydroxyurea for 10 months though I had to stop in between those months when my wbc was 1400 or less.

I did a JAK2 V617F Mutation. 
I have been on Imatinib for 8 years now and yes I have been on Hydroxyurea for 10 months though I had to stop in between those months when my wbc was 1400 or less.

Were you in MMR and generally feeling well for the time you were on TKI?  I found this article which shows successful treatment of both CML and the mutations you mention, although they appear to be unrelated and perhaps need to be closely monitored and treatments cycled.

https://www.thejh.org/index.php/jh/article/view/591/468

Scary 😧 

I was feeling fine when I was on TKI