You are here

Relapse

Hello,

I was wondering if there is anyone who has any ideas of what I can potentially be looking out for:

I was diagnosed in accelerated phase in 2016, and started with Imatinib 800mg (had to change later). I ultimately had a good run with TKIs and was almost back to my normal self until in 2022 I started having severe ulcers as well as other side effects, due to which I had to stop TKIs. Unfortunately, now I need to re-start but there is a mutation (t315i) and honestly I am not sure - given that I was not able to tolerate side effects - how things are going to work out. I know that Scemblix/asciminib is a possible solution (though not very practical as it does not yet have regulatory approvals in the country where I am based). I wonder if anyone on this forum is aware of any newer developments that I could track? [And regarding stem cell transplants, I have always for some reason been very scared of that... but it is probably time to at least think about it...]

Ponatinib can combat T315i. Try as low of a dose as you can and still keep your BCR/ABL under control. This would be preferred in my opinion over transplant. I would try low dose or intermittent dose before I would consider other options. Hope you find a great outcome.

Asciminib isn't indicated for t315i, though it does have some efficacy for this particular mutation.

Ponatinib is the "go to" TKI for t315i, and often at a lower dose than the standard 45mg one to reduce side effects.

Where are you treated?

Thank you, I am being treated in India... I unfortunately cannot get on ponatinib because of a heart arrhythmia which the doctor says that I cannot consider ponatinib

Thank you very much... :)