From what I have read, there are many ways to cure CML. Unfortunately, short term fasting is not one of them. It may block or even reverse ALL/CLL, but it seems to have little effects on AML/CML. Short term fasting is anything between 1 and 7 days. In the published studies, where it's (incorrectly?) called "prolonged" fasting, they usually went for 48-72 hours.
https://share.google/aimode/qjRxdz8SncDNlQ2qn
TKIs do not affect LSCs even if these are awaken.
Kinase-Independent Survival: Unlike mature leukemic cells, LSCs are not oncogene-addicted to BCR::ABL1 signaling and can survive even when the kinase is completely inhibited.
https://share.google/aimode/uvd7KlC2oHXfT6zVs
I have read several books on fasting for restoring health and there it's clearly distinguished between preventative fasting (1 - 7 days) and therapeutic fasting (12 - 40 days). Most people can go through the first one on water, tea and coffee without major issues. For the second one, you need to deal with the issues and risks related to metabolic acidosis and catabolic state. Most people can overcome these with bone broth and veggie juice. You can also use bicarb soda or purchase fasting salts to maintain low acidity and sufficient levels of electrolytes. But every person is unique, so should be extremely careful. People with low body fat should not fast at all.
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I recommend reading Upton Sinclair's book https://archive.org/details/fastingcure00sincrich/mode/2up and also Jason Fung's one
https://www.amazon.com/Complete-Guide-Fasting-Intermittent-Alternate-Day...
If you are more into watching stuff, there is an informative doco on Youtube https://www.youtube.com/watch?v=xaZOwwauuvc
I had managed to fast several times for up to 4 days while on Dasatinib and it felt great, but had no effect on BCR. While on Asciminib, it feels very difficult to get beyond 24 hours. Now I'm going to try it with the help of bone broth and Breuss veggie juice. Some people use fruit juice, however, even though for example apple and beetroot juice both contain around 10% sugar, apple juice spikes blood glucose while beetroot juice suppresses it. My goal is to reach at least 12 days and push for 21 and then repeat it from time to time.
In my last conversation with AI on natural leukotriene inhibitors, it mentioned parthenolide and its synthetic variant dimethylamino-parthenolide which is 1000 times more bioavailable and very effective in selectively eradicating LSCs from the bone marrow with no effects on healthy cells. Several universities have been looking into it in relation to AML, but I wouldn't hold my breath waiting for its commercialisation as there is no money in it. The first compound I found years ago that could cure CML was Tenovin-6 as described in the paper published in 2012. I assume Tenovin-6 cannot be patented, just as figuring out delivery mechanisms for many natural products that could improve their bioavailability and effectivenes against CML LSCs, so no one is seriously looking into it.
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https://pmc.ncbi.nlm.nih.gov/articles/PMC3285436/
It is a sad reality that today only profit drives research and innovation. As my friend explained to me, he obtained PhD in pharmacology working at a uni lab fully sponsored by Pfizer, project financial evaluations are performed quarterly and regardless of the stage of a project it can be scraped in a day if its financial prospects change. The knowledge and insights obtained through scraped projects are sealed and shelved at the sponsor's internal data storage, considered as confidential private property and strategic advantage, never to be released to public.
https://www.mordorintelligence.com/industry-reports/chronic-myelogenous-...
https://www.mordorintelligence.com/industry-reports/tyrosine-kinase-inhi...
