Your doctors are 'ignorant'. Low dose does not cause mutations. Low dose may or may not work depending on "you" - the patient. You are unique. Finding the correct dose is what matters.
You have to keep in your mind that your doctors are licensed physicians who are at legal risk if they depart from established protocols. But, they are also expected to keep learning. Eventually, enough doctors will be applying new protocols that by NOT giving you dose modification, they could be guilty of malpractice. It takes time. Your doctors do not want to 'risk' being out of the mainstream of practice. I can appreciate their concerns given our litigious society - but that doesn't mean they are practicing medicine with you front and center. In the back of their mind, liability is a big concern.
Research oncologists, however, have a different motivation. They want to be famous! Discovering "new", being "first", setting the trail, is their motivation. They are the ones who publish papers by the bucket load. They are sought out for their "opinions" and advice. In the clinic, they want to apply what they have learned first before anyone. They tend to be very smart people.. And arrogant. I like researchers. They lead in clinical trials where they learn (even if the trial is a "failure") what may work and not.
And then there is "US" - the patients who live with this disease. We know the most - collectively. We really do. On this forum and elsewhere, we learn from other patients what they have done, seek to do and who their doctors are (both research and those who practice). We have access to the full range of debate, approaches and what has / has not worked for them. We can't "sue" ourselves by trying something and it doesn't work. We have to be our own best advocate and use the professionals as advisors. In some cases we know more than them (like you now know more about dosing than your doctors). To be honest, my doctor is now just a lab tech for me. Take the blood samples, run the tests and give me the results. I'll take it from there. If something strange turns up, I'll seek an expert 'in that area' - who....publishes papers. And if I benefit from this new experience - I'll share it .... on this forum.