I saw my haematologist yesterday and was told my BCR ABL result had risen from 0.05 to 6+ in 3 months. I’m a bit concerned as he is changing my TKI to BOSUTINIB. This will be my third TKI as I’ve already tried Imatanib and Nilotinib, having had bad side effects with these two. I’m concerned as I may have side effects on this one.
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Lack of response on Nilotinib
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If I understood your post correctly and you were at 0.05% (MMR) and have gone to >6.0% then it is a good idea to switch as there may be a mutation that another TKI would do better with. I do not understand how you were switched to Nilotinib from Imatinib if you had not responded to Imatinib since they work similary (Nilotinib naturally more potent).
I would request a re-test to confirm since you were/possibly are in MMR as lab errors, although rare, do occur. If confirmed I would insist on mutation testing before any switch is made. In other words without a mutation test you could be moving to Bosutinib while harboring a mutation that Sprycel or Ponatinib would be more effective with. Just my thoughts but I'm sure others will provide reassurance and insight. Hope you get the appropriate TKI working soon. Take care.
Thank you for your reply. I was having extremely bad bone pain on imatanib and not really responding. When I went on to Nilotinib, my response was very quick, although I was having bad side effects. I have had two test results where my BCR ABL has increased. From 0.05, then to 0.5 and finally to 6. I’m seeing my nurse in a week to discuss things. I don’t really understand why my results keep rising.
You’ve probably already been asked this question by your doc and presume your adherence to the strict 12 hour gap between meds on Nilotinib. And also missing no doses? Also are you on 600mg or 800mg. 600 is the standard but 800 is for those who are imatinib resistant.
I hope this gets sorted for you. A stressful time I am sure.
Alex
Hi,
Your post is not correct, you are bit confused, go re check the lab, MMR to 6 + it's not possible. Plaese re check and confirm the lab.
Thnank
Hi thanks For your understanding . Unfortunately I am having problems taking the Bosutinib. It’s really having bad effects on my digestive system. I have ten days to go before I see my haematologist.
Hi Maggi,
have you checked with your doctor that the anti-sickness tablets you take are not contra-indicated with bosutinib?
Sandy
I am also on Tasigna. My own experience is the effectiveness of this TKI is largely dependent on how well it is absorbed. When I changed fasting time from two hours to at least three hours. My PCR started to drop (before that it stayed high). If I have digestive problem during the period, then my PCR will go up again. I think digestive issue causes body absorbing only a fraction of the medicine, hence the drug will not work to its full potential. It does not necessarily mean that you are resistant to Tasigna.
I am interested in your claim about absorption. You mentioned when you changed from 2 - 3 hours you saw drops. I am on this TKI and the standard is to fast for 3 hours not 2 by default x2 times daily 12 hours apart could you elaborate please? As I am confused by your comment. If I got it correctly you went against the guidelines and was doing 2 hour fasts then moved to 3 is that correct?
Many thanks
Alex
Hi ,
I think he means people with digestive problems. Absorption is increased with food intake wich is why we have to fast not the other way. If you wanted to increase absorption with a healthy stomach you would need to eat closer to intake . My recommendation is also two hours prior to eating maybe in the uk you have 3 hours. I think it used to be one(saw it in a couple of studies), it was increased because some patients probably had adverse reactions.
Take care!
Hey,
No it’s a 3 hour fast 2 hours before meds and 1 hour after is the standard across the board x2 a day 12 hours apart. So yeah my question was is he fasting only 2 hours (which is incorrect for Tasigna should be 3 in total).
So basically I take my meds at 8am and 8pm which means I cannot eat from 6-9 twice daily.
Thanks man
Al