Hi Annie
The 2 month result does not say anything at all really. Some conclusions can be drawn from a statistical point of view from a 3 month result but even that is not definite. Trend is important, even if it is slower then expected in the guidelines. So try not to worry, although I am in a similar position as you being 7 months in.
The milestones often referred online and by doctors are valid for a large patient cohort and you can not take a single patient and always strictly put them in the guideline context. Many factors must be taken into account. At least that is what was explained to me.
As a reference, after 3 months on imatinib I was 16 %. Then a switch to nilotinib low dose due to cytopenias and I was 11 % at 4 months and then 18 % after 6 months (I had a drug holiday on month 5). The last test got me overly worried of course.
But my case also reflects the imperfection of PCR testing since my 6 month FISH result was 16,6 % (coming down from 60 % at 5 months). And FISH or cytogenetic evaluation by counting cell metaphases is more reliable in the early days. The pathologist counts the actual CML cells under the microscope and calculates a ratio from healthy cells.
To sum up in regards to PCR, focus on the trend rather on the pace and always remember that PCR testing can give quite inaccurate or nonsense results in the early days.
When it comes to supplements, vitamin D is crucial. I would consider having vitamin D levels tested. There are advocates on this forum who strongly suggest high vitamin D consumption and I also belong to that group. I also had this recommended by my haematologist.
Folic acid in necessary for bone marrow recovery and vitamin C boosts immunity (together with vitamin D). Both are needed
Vitamin K2 is needed to balance a bit the high intake of vitamin D. Excessive consumption of vitamin D can make your blood vessels less plastic and that would be bad for your cardiovascluar health. Together with vitamin K those risks are mitigated.
Search this forum with the keywords "vitamin D", "vitamin K2". You will find a lot of trustworthy data from long-time CML people.
Have you had a heamatological response? If yes, then this is a sign that the medication is working. Focus on adherence and nutritional support :)
Timo