Interested in real life experience:
Has anyone taken Quercetin and dasatinib (Sprycel) and had their BCR ABL decrease further? I am concerned that it could be bad for CML response.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218402/
“Unexpectedly, D+Q alone appeared to have acute pro-tumorigenic effects in control mice.”
Also on Web MD: if you add quercetin to imatinib or nilotinib (not on any other TKI) it says : “ Quercetin will decrease the level or effect of Nilotinib by affects how the drug is eliminated from the body (via what is known as the P-glycoprotein [MDR1] transporter).”
https://www.webmd.com/interaction-checker/default.htm
I know I am taking a small sentence out of a study and comparing apples and oranges and that my TKI dasatinib is not listed as having a side effect, however I think many of us might be supplementing despite unknown side effects. I am not concerned about aging, just wanting to actually have the privilege of getting old in the first place (most dasatinib/quercetin studies are age related). My BCR ABL increased when I added quercetin. I have since stopped every single supplement except for D3K2 because I am a bit freaked out, not only by my higher number but also with how I am feeling (which might be anxiety),… I have tingling in my legs again which was the reason why I went to the doctor when I was first diagnosed with CML. Really praying the next BCR ABL gives me peace of mind. I will update you with my next BCR ABL number which come out beginning of August.
Please be cautious everyone! I feel the need to warn people.
Thanks!