Just found this message board. I’m 42 and was diagnosed with CML last Oct with bcr-abl transcripts >50%. I was put on Imatinib right after diagnosis and went into complete hematological remission almost immediately, but my bcr-abl levels only went down to 17% after 6 months on Imatinib and were at 20% after 9 months on treatment despite staying in complete hematological remission. I was just switched to Nilotinib in an effort to bring down my PCR results. I just wanted to get everyone’s thoughts on why I’m doing so well hematologically, but my transcript levels are so stubborn? Also wondering if this stubbornness of my transcript levels means I’m likely to have a poor prognosis and if I should be considering more aggressive options earlier on (i.e. transplant)Any thoughts would be greatly appreciated. Thank you!