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Rocky Mountain Gal on 23 July 2022

Category: Blood tests

Replies: 1

Last updated: 6 August 2022

Fasting and CBC draw
by JoeP (Aug 6)

I used to fast a lot. It seemed to help even before a blood draw. But not sure the results are definitive with fasting. For one thing I know when I did fast under imatinib it actually was not good

by Rocky Mountain Gal (Jul 23)

I am finishing a 3 day fast today. Not as bad as I thought! Question: Should I go in for my blood draw before or after I break my fast?
Category: Blood tests

Replies: 1

Last updated: 6 August 2022
Batman0424 on 25 July 2022

Category: Blood tests

Replies: 1

Last updated: 26 July 2022

Low Counts?
by alexmcpee (Jul 26)

MartinZA who posted a similar question on here is in a similar position with all of a sudden low counts although as far as I know his BCR is still ok - your wife is no doubt having a 2nd biopsy

by Batman0424 (Jul 25)

Hello,
My wife was diagnosed with CML in November 2019 and has been on dasatinib since. Her counts have always been low, but recently her dr's office has suggested that a bone marrow
Category: Blood tests

Replies: 1

Last updated: 26 July 2022
vineet on 15 July 2022

Category: Blood tests

Replies: 3

Last updated: 25 July 2022

observed immature granulocytes cell(0.2%) in blood report achived mmr 9 months ago
by Tater1 (Jul 25)

Hi. I have had higher immature granulocyte counts periodically and when asked my Dr responded that they see these numbers come up in many patients from time to time. He emphasized that

by MartinZA (Jul 25)

Hi there
I'm not a doctor so don't want to say too much about the immature granulocytes except that I thought these were associated with inflammation, not leukaemia (I thought they are

by An (Jul 17)

Isn't immature granulocytes and basophils within range?if hb is low rdw will be low.

by vineet (Jul 15)

hi all , i am cml patient in sept 2019,my recent bcr abl test was on may-22 last week and i was in mmr (0.04 IS scale).i am on dasatanib. my wife asked me to do full body
Category: Blood tests

Replies: 3

Last updated: 25 July 2022
ishb1 on 28 April 2021

Category: Blood tests

Replies: 2

Last updated: 16 July 2022

How do you read your BCR test/transcript?
by Reilly9108 (Jul 16)

My number is .17
p190 .17
p210 negative
is negative and undetected mean the same thing

by RC Kirk (May 1)

Sounds like normal CML. Here's what my report said at diagnosis: "p210 transcript b3a2 and b2a2 118.683% IS (88.57%), p190 transcript e1a2 0.01%"
My report didn't separate the b3a2

by ishb1 (Apr 28)

Doctor ordered a BCR ALB1 Tests and it has examples of
B2A2 Transcript
B3A2 Transcript
Do you all know how to Interpret the results? for instance, it gives me a percentage by each transcript.
Category: Blood tests

Replies: 2

Last updated: 16 July 2022
Reilly9108 on 14 July 2022

Category: Blood tests

Replies: 0

Last updated: 14 July 2022

BCR ABL1 Results How to Interpet
by Reilly9108 (Jul 14)

Hello
Looking for a answer ..I was Negative for 1 1/2 year now last Lab results 7/5/2022 shows e14a2 b3a2 results 0.1714 positive
e13a2 b2a2 Negative
What would make part of this
Category: Blood tests

Replies: 0

Last updated: 14 July 2022
beero on 16 July 2021

Category: Blood tests

Replies: 6

Last updated: 7 July 2022

18 months - PCR increase
by JoeP (Jul 7)

If you are consistently getting at least 2 zeros after the decimal after only 18 months I would say you are doing stellar. And that’s on Imatinib? I was 11 years on that and reached .003 once

by beero (Jul 7)

I have the update on this after my latest test couple of days ago.
After the "negative" (under 0.0032) result 6 months ago, I again received a "suspicious" result - 0.0030.
The

by Nimbus2 (Jan 13)

I notice in my own case that I have 10 BCR::ABL1 cells in 39,106 copies of ABL1, i.e. 10/39,106 x 100 x 0.6 [laboratory correction for IS] = 0.0153%
I am still in MR3.
I would need, as I see it, to

by beero (Jan 12)

Hello guys,
I owe you an update on this thread. Just got the message from my doctor and my latest BCR-ABL says undetectable.
However, it doesn't really mean I've got a lower result than last
Category: Blood tests

Replies: 6

Last updated: 7 July 2022
snowman 35 on 25 June 2022

Category: Blood tests

Replies: 6

Last updated: 26 June 2022

Creatinine levels
by snowman 35 (Jun 26)

By drinking more water levels went down!sometimes close to normal range sometimes higher(mostly in hot days)but definitely lower than if was drinking less....

by snowman 35 (Jun 26)

I am not on imadinib....all the tests and the ultrasound was perfectly normal!

by wshi2001 (Jun 26)

By the way, its got nothing to do with drinking more water. My doctor said the same thing, drink more water, I tried, and did not make any difference, it's the drug's side effect.

by wshi2001 (Jun 26)

hi, when I was on Imatinib, I had the same problem. When I changed to Tasigna, it settled down. I read some article suggesting there was cases that imatinib causing kidney damages
Category: Blood tests

Replies: 6

Last updated: 26 June 2022
Taper11 on 4 June 2022

Category: Blood tests

Replies: 2

Last updated: 6 June 2022

BCR ABL Increase at 9 Mts
by Taper11 (Jun 6)

Thanks for putting this in perspective Alex, I really appreciate it.

by alexmcpee (Jun 4)

Don’t ever apologise. We all have to air our concerns wether repeated or not, it’s part of our mental healing as much as it is our physical healing.
This thing can bounce around like a

by Taper11 (Jun 4)

Apologies for creating a thread when I know there's so many others on this topic, but I am just looking for some reassurance.

I've been taking 100mg dastinib since September
Category: Blood tests

Replies: 2

Last updated: 6 June 2022
EvaH on 9 May 2022

Category: Blood tests

Replies: 6

Last updated: 15 May 2022

Back in TFR - happy days!
by Sav_5 (May 15)

Great news EvaH!!

by Sherley (May 10)

That’s great news!

by Sunny (May 9)

Lovely news EvaH. With so much bad news nowadays, nice to hear good news for a change.
All the best,
pigeon.

by Buzzm1 (May 9)

Happy for you Eva!
Buzz
Category: Blood tests

Replies: 6

Last updated: 15 May 2022
johnw1001 on 5 May 2022

Category: Blood tests

Replies: 7

Last updated: 9 May 2022

Lymphopenia
by scuba (May 9)

Conversion factor: 1 ng/ml = 2.5 nmol/L
60 - 80 ng/ml = 150 nmol/l - 200 nmol/l

by sandy craine (May 9)

Just to remind you that in the UK (and other EU countries) D3 is measured in nmol/L rather than ng/ml so you would need to convert your test result if you are following US based research/

by johnw1001 (May 6)

Chrissie,
I would not expect a GP to have in depth knowledge of how Vit D impacts on the immune system and nor would I expect them to understand the mechanisms of CML and how tkis themselves may as

by chrissie (May 6)

A question - why are my GP and haem both happy with my current Vit D levels at 53. I have been taking 1400IUs daily for a couple of years after my levels were " low". I shall continue on
Category: Blood tests

Replies: 7

Last updated: 9 May 2022
cmhall604 on 11 April 2022

Category: Blood tests

Replies: 2

Last updated: 16 April 2022

Immature granulocytes in peripheral blood
by cmhall604 (Apr 16)

Hi Sandy,
Thanks very much for your reply. Got the results back yesterday and she's back to PCRU! I guess a little bit is nothing to worry about.
Cheers,
Chris

by sandy craine (Apr 13)

Hi Chris,
From what I understand, I don't think you need to be concerned. The appearance of myelocytes (1%) in your wife's peripheral blood is is probably due to an infection.
"

by cmhall604 (Apr 11)

Hello, I haven't posted in quite a while but my wife just had another checkup so I'm back with another question. She has been doing well over the past two years since diagnosis, reaching
Category: Blood tests

Replies: 2

Last updated: 16 April 2022
Myra on 5 April 2022

Category: Blood tests

Replies: 7

Last updated: 11 April 2022

Same PCR level from last 3 times
by ColoradoGuy (Apr 11)

I would say that I normally see a plateau for three test results before it goes down again. My plateaus normally include at least one result that goes up from the previous results. They

by hannibellemo (Apr 8)

Myra, I know it's disappointing to hit a plateau but in terms of survival you are at a very safe spot. I love how doctors say what they want when, other than taking our meds as directed, we have

by scuba (Apr 8)

Something to keep in mind is that once you achieve complete cytogenetic remission (CCyR), progression free survival rates are no different statistically than with patients who achieve deeper

by Myra (Apr 8)

I get your point that it's a safe place to me with such low level. In the starting the response to Dastanib was very good and within a year the value was 0.14... but now there is a plateau and
Category: Blood tests

Replies: 7

Last updated: 11 April 2022
VinayJagnani on 17 March 2022

Category: Blood tests

Replies: 5

Last updated: 19 March 2022

BCR-ABL %
by JohnFromChicago (Mar 19)

Age 34 here I was diagnosed at 28 my PCR result bounces between .02 and .08. Seems as of recent people have been seeing more fluctuations in their PCR results as well. I believe this maybe due to

by ColoradoGuy (Mar 19)

I would not say that it is common but it is nothing to worry about. Being under 1% good news, and .026 even better. I don't know your age but I have noticed on this and other forums that younger

by VinayJagnani (Mar 18)

Hello Friends,
Thanks everyone for the response. Its so reassuring to hear so positive response and happy to hear that this is common.
I feel so much better now.
Thank You.

by ColoradoGuy (Mar 17)

There is no reason to increase dose at these levels. You can remain here for months before you see another drop. Or it can increase slightly before coming down again. It is like small ripples
Category: Blood tests

Replies: 5

Last updated: 19 March 2022
Deni H on 14 January 2022

Category: Blood tests

Replies: 10

Last updated: 17 March 2022

BCR ABL Increase
by Norma_55 (Mar 17)

Hi there don’t worry too much about the bone marrow biopsy it’s not as bad as you think it might be, I had one in 2020 from the hipbone.
and as far as side affects from treatments go not

by Deni H (Feb 23)

Thanks Sandy.
I think they are starting me on Dasatinib when I go back in 2 weeks. I had another Bone Marrow Biopsy yesterday to get a good base line.
Any ideas what possibly to expect with side

by sandy craine (Feb 22)

Hi Deni,
Sorry to hear you have developed a mutation but don't worry too much. I assume your clinician has already identified the particular mutation and will let you know what it is?
There are

by Deni H (Feb 21)

Hi All
I hope you're all well.
Just an update from my post in January. I saw my consultant today who has confirmed a mutation in my recent BCR ABL and increase to 1.9 from 1.16 in November.
So
Category: Blood tests

Replies: 10

Last updated: 17 March 2022
steven7 on 13 March 2022

Category: Blood tests

Replies: 4

Last updated: 16 March 2022

Change lab and BCR result increase
by johnw1001 (Mar 16)

Hi
Most specialists would not be that concerned with your figures because if your PCR score is less than 0.1 then you are in safe territory and very much in MMR.Even if you were above 0.1 and

by sandy craine (Mar 14)

Hi Steven, I hope so... but the project to ensure the standardisation of labs using PCR for CML (known as international standard - IS) has been a challenge over the years.
Best to you,
Sandy

by steven7 (Mar 14)

Thanks sandy.
I am in Canada so hope that's less problematic.
Anyone who got same experience please share.

by sandy craine (Mar 14)

Hi Steven,
The problem with changing labs is that they may be using a different 'housekeeping gene' that that used by the first lab... plus there may be other issues to do with expertise and
Category: Blood tests

Replies: 4

Last updated: 16 March 2022
jb on 11 March 2022

Category: Blood tests

Replies: 1

Last updated: 14 March 2022

Please advise
by sandy craine (Mar 14)

Hi JB, concerning your ANC. I am not sure your should be too worried about with this result - 1.6. According to the reference ranges- see link here as long as ANC is above 1.5 there should

by jb (Mar 11)

I recently received the results of my latest PCR BCR/ABL and there was a slight increase in my numbers. Also, my WBC and Absolute Neutrophils have dramatically dropped to below the low norms.
Category: Blood tests

Replies: 1

Last updated: 14 March 2022
ishbc6 on 19 February 2022

Category: Blood tests

Replies: 3

Last updated: 21 February 2022

HELP!! DR Wants bone marrow biopsy: Currently on Tasigna
by ColoradoGuy (Feb 21)

They probably want to run a karyotyping test to see if there are any other additional chromosomal abnormalities rather than looking for percentage blast cells. That of course is just a guess,

by ishbc6 (Feb 19)

I was diagnosed in October 2020. Had one bone marrow biopsy, now they want to do another one. I had a mutation test when I switched from Imatinib. Came back normal I am assuming, because I didn

by johnw1001 (Feb 19)

Hi,
There have been some postings here on Forum in the past re the use of the bone marrow biopsy as opposed to relying on the much less invasive use of peripheral blood i.e.the pcr of bcr/abl.The

by ishbc6 (Feb 19)

Hello All,
I am currently taking Tasigna 150 MG 3 times a day for a few months now. BCR is slowly coming down, however my Platelets have dropped for the last 3 months, as well as my WBC, ANC. I was
Category: Blood tests

Replies: 3

Last updated: 21 February 2022
Danmason11 on 15 February 2022

Category: Blood tests

Replies: 3

Last updated: 15 February 2022

First BCR-ABL results sub optimal
by sandy craine (Feb 15)

Hi Dan,
Yes I understand. Queen Elizabeth hospital is a centre of excellence for CML etc. so maybe you could ask for either 'shared care' or preferably a referral? 4-5 weeks seems an overly

by Danmason11 (Feb 15)

Thank you so much for the reply Sandy, I really appreciate it.

I am being treated in Wolverhampton, and must admit to feeling a bit let down in terms of care and support aside from

by sandy craine (Feb 15)

Hi Dan,
It's really difficult not to be anxious when first diagnosed. Your doctor's use of the term 'sub-optimal' will not have done anything to reassure you, but their qualification

by Danmason11 (Feb 15)

Hi all
i was diagnosed in August 2021 and started in 400mg Imatinib. Had my first blood test in November, but never got told the BCR-ABL results until today. I had my second blood test last week, so
Category: Blood tests

Replies: 3

Last updated: 15 February 2022
Gian P on 3 February 2022

Category: Blood tests

Replies: 2

Last updated: 4 February 2022

CAR T CELL Treatment Cure for Leukemia
by Gian P (Feb 4)

I share this with my Onco doctor, she told me that this therapy is the last resource and can be very toxic for the body with high mortality rate... i am guessing is not for everyone, but, yes, i

by ColoradoGuy (Feb 4)

Wow. That is amazing. Great news for those with CLL. I remember when I was diagnosed being told that if you were going to have cancer CML was the one you wanted....Maybe not the

by Gian P (Feb 3)

I was reading about this article and found it very interesting, I figured to share it here.
https://amp.cnn.com/cnn/2022/02/02/health/cancer-t-cell-therapy-remissio...
Category: Blood tests

Replies: 2

Last updated: 4 February 2022
EvaH on 18 August 2021

Category: Blood tests

Replies: 42

Last updated: 3 February 2022

Here goes - first bcr/abl after dose reduction
by Gian P (Feb 3)

Vodka sounds great! I might have some 60 mml around... i can start with those;)
thank you!

by EvaH (Feb 3)

Oh lordy, triangle tablets...not easy!
Maybe you can dissolve them in something (vodka?) and use the required amount of liquid each day.

by Gian P (Feb 2)

i will definitely start that routine and keep everyone posted about the results, Buzz thank yiu for taking your time and articulate the process, i am still not sure how precise my splitting of the

by Buzzm1 (Feb 2)

Gian, based on the results of at least your last four quarterly BCR-ABL tests, you are in a plateau and should be able to begin gradually reducing your TKI dosage. For the benefit of others,
Category: Blood tests

Replies: 42

Last updated: 3 February 2022