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gbatalha on 29 April 2020

Category: Blood tests

Replies: 3

Last updated: 29 April 2020

BCR ABL 24 Months
by scuba (Apr 29)

This is why blood testing is so important, because it can guide you how much vitamin D you need on a personal basis. I presume you meant "IUs" daily.
To double your blood level (from 30

by gbatalha (Apr 29)

4000 DUs daily.
My levels are at low 30s ng/ml with the daily supplement.
PS - My skin is very dark, quasi-northern african

by scuba (Apr 29)

How much vitamin D3 do you take per day? Do you know your vitamin D blood level?

by gbatalha (Apr 29)

Hi everyone,
Just wanted to share my recent results to give everyone some level of comfort around variations of BCR-ABL levels (42 years old/400mg Imatinib daily/low risk at diagnosis):
12M - 0,150
Category: Blood tests

Replies: 3

Last updated: 29 April 2020
Gian P on 20 April 2020

Category: Blood tests

Replies: 9

Last updated: 20 April 2020

My doctor increased dosage and now i feel like hell...
by snowman 35 (Apr 20)

You 'Re wright. 😉

by Gian P (Apr 20)

Sounds Good.
I will use the search, i am sure he covered it once or twice already.
Thank you again

by snowman 35 (Apr 20)

You should get Scuba's advice for this! He is the expert! I do not want to tell you something wrong...

by Gian P (Apr 20)

Okay
how much Curcumin should i take daily?
500 mmg okay?
Category: Blood tests

Replies: 9

Last updated: 20 April 2020
Karthikeyan on 9 April 2020

Category: Blood tests

Replies: 1

Last updated: 9 April 2020

To scuba and others about cbc
by scuba (Apr 9)

Many who participate on this forum can provide answers and comments to your questions. A variety of answers can help you decide what is a good course of action that you may want to take.
Not taking

by Karthikeyan (Apr 9)

Hi, i was diagnosed exactly five years ago. But i have very little knowledge about cml as i have completely surrendered myself to my oncologist. So i kindly request scuba and other forum members to
Category: Blood tests

Replies: 1

Last updated: 9 April 2020
Karthikeyan on 6 April 2020

Category: Blood tests

Replies: 1

Last updated: 6 April 2020

To scuba about pcr result
by scuba (Apr 6)

It means you are going to live a very long life.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786836/
Just an FYI : patients often show initially both p210 and and to a much lesser degree p190

by Karthikeyan (Apr 6)

HI,

RESULT P210 (b3a2, b2a2) major transcript Detected

P190 (e1a2) minor transcript Not detected P230 (c3a2) micro transcript Not detected Observed copies of ABL1 163664
Category: Blood tests

Replies: 1

Last updated: 6 April 2020
Justine on 31 March 2020

Category: Blood tests

Replies: 3

Last updated: 2 April 2020

Article on CML lab testing
by kali (Apr 2)

Thank you for sharing this great article.

by alexmcpee (Apr 1)

Wonderful write up. And very informative.
Thank you
Alex

by scuba (Mar 31)

Justine - Thanks for the link. Excellent summary.

by Justine (Mar 31)

My brother, who is a pathologist in the US, sent this article. It may be of interest.

https://www.captodayonline.com/in-cml-bcr-abl-monitoring-takes-on-new-im...
Category: Blood tests

Replies: 3

Last updated: 2 April 2020
koralia.pappi on 4 March 2020

Category: Blood tests

Replies: 8

Last updated: 13 March 2020

Ways to measure D3
by onekayaker (Mar 13)

Thanks and yes I use k2....Full Spectrum puts out a k2 with mk4 and 7. I was taking k2 twice a day same as the d3.

by scuba (Mar 11)

Hi Steff,
Stopping is o.k. - it takes months for vitamin D to drop only by half - and it takes months to build. Make sure you are taking vitamin K2 every day as well (200 mcg). K2 uses D as it moves

by onekayaker (Mar 11)

ok I will go to 5,000 ui per day. I am a bit afraid to stop completely since working at a airport now I come into contact with many people. I miss the solitude of my old career.

by scuba (Mar 6)

I had that happen once where I tested at 100 (transition from winter to spring). What I did was stop taking vitamin D3 completely for 3 weeks and re-test.
It takes about 60 days for 1/2 of vitamin D
Category: Blood tests

Replies: 8

Last updated: 13 March 2020
bendicco on 29 February 2020

Category: Blood tests

Replies: 7

Last updated: 1 March 2020

Blood Draw Kit
by bendicco (Mar 1)

Thanks David, that’s very helpful. Yes I would have the nurse do it! I’m assuming that Sloan will send it to me and include a return label , FedEx overnite I guess. I hope that the test

by David Fitz (Mar 1)

Once, yes. We needed to test my sister for HLA matching with me, but she lives abroad so they gave us a blood kit to give to someone there. We actually just did it ourselves because she and my step-

by bendicco (Mar 1)

Thanks David. Have you personal experience with the kit?

by David Fitz (Mar 1)

Various anticoagulants and preservatives are used and can be identified by the colour of the collection tube.

Purple: EDTA. Commonly used for FBC tests.
Blue: sodium citrate. Used for tests
Category: Blood tests

Replies: 7

Last updated: 1 March 2020
Mosalem2093 on 15 February 2020

Category: Blood tests

Replies: 2

Last updated: 16 February 2020

BCR_ABL test and Sprycel
by Mosalem2093 (Feb 16)

Thanks a lot David. ..
I think he was at 36% at the last Tasigna results which let them decide to switch over to Sprycel..I hope that by time he can get to the good levels. He has 100mg Sprycel

by David Fitz (Feb 16)

Hi there, and welcome.
18% after 2 months is pretty good. The “optimal” result at 3 months is 10% - and if at 18% at 2 months I would expect him to achieve that optimal result at 3

by Mosalem2093 (Feb 15)

Hi all,
I am new to this forum. My dad has CML and they switched him from Tasigna to Sprycel as doctor claims it's not working given the subject test recent results. He suffers from side effects
Category: Blood tests

Replies: 2

Last updated: 16 February 2020
Chuckster on 11 November 2019

Category: Blood tests

Replies: 12

Last updated: 16 February 2020

Latest Blood Test Results BCR/ABL1 .
by Mosalem2093 (Feb 16)

Hi Scuba,
Do you have a link to these ASH papers that Sprycel 20 mg is effective as my dad has similar case and would like to share it with his doctor,

by Chuckster (Feb 15)

Thanks Scuba!
I am so glad my oncologist agreed with me to ride this past six months out by staying with the 20 MG Sprycel dosage than trying a different Med.
20MG, so far, seems to be

by scuba (Feb 15)

Cool. You know I am not surprised!
(Kat - I believe there were several papers at ASH on low dose sprycel's effectiveness (20 mg). I'll have to find them again)

by Chuckster (Feb 14)

THANKS!
Category: Blood tests

Replies: 12

Last updated: 16 February 2020
koralia.pappi on 6 February 2020

Category: Blood tests

Replies: 3

Last updated: 7 February 2020

hsCRP levels
by David Fitz (Feb 7)

Well I imagine flu could certainly increase CRP - stands to reason I guess but I’m no expert. Keep an eye on it, and if your doctor isn’t fussed about it make sure you get a really good

by koralia.pappi (Feb 7)

Hi David,
My doctor disregards this as a non-issue. Specifically for the last reading, I think it is also kind of expected, because all readings are a bit high due to the flu (WBC 10.4, ESR: 21,

by David Fitz (Feb 7)

CRP - I only remember that one because it was a topic of constant conversation with doctors when my twins lived in the hospital. It’s a marker for inflammation if I remember rightly and I

by koralia.pappi (Feb 6)

Hi all,
Question on hsCRP:
My levels have been around 0.8-0.9 mg/dl for the last 3 lab tests (Sept, Nov, Feb), with a normal value of <0.3mg/dl according to my lab.

So what's with this
Category: Blood tests

Replies: 3

Last updated: 7 February 2020
Vikram on 13 October 2019

Category: Blood tests

Replies: 15

Last updated: 7 January 2020

Cbc report
by Vikram (Jan 7)

Thanks for your reply....

by RC Kirk (Jan 5)

Hi Vikram,
The PCR test for BCR/ABL1 is the most sensitive test for PH+ CML. If your PCR score has been undetectable for the past 8 years, then it's likely that your CML will remain

by Vikram (Jan 5)

Any idea...... Please reply....

by Vikram (Jan 4)

Only for information......Perpous......
Last 8 years UNDETACTABLE
CBC REPORT not diagnose cml current time
(1) Fish test born merrow test diagnoses I cml.......???? (last 8 years UNDETACTABLE
Category: Blood tests

Replies: 15

Last updated: 7 January 2020
ipmaki on 31 December 2019

Category: Blood tests

Replies: 3

Last updated: 2 January 2020

Absolute Neutrophil Bands
by David Fitz (Jan 2)

Flu shot can definitely cause a drop in white cell counts in general, and of course that includes neutrophils. There’s a fair bit of research on Medline about neutropenia and vaccinations that

by ipmaki (Jan 2)

Hi David,
Thank you for the information. I am getting over a flu from about 3-4 weeks ago which turned into a sinus infection. So maybe that explains the low ANC? I just thought there would be a

by David Fitz (Jan 2)

ANC of 0.6 is a little low, indeed. Have you been ill at all recently? Your neutrophil count can be affected by a recent virus, for example.
Neutrophil bands are, to my knowledge, neutrophils that

by ipmaki (Dec 31)

Just curious, I couldn't find any information on this subject in previous posts. I recently had absolute neutrophil bands show up in my CBC (0.4 K/uL) and I was curious what this means. My
Category: Blood tests

Replies: 3

Last updated: 2 January 2020
Tater1 on 24 December 2019

Category: Blood tests

Replies: 2

Last updated: 25 December 2019

Medication Hold
by Tater1 (Dec 25)

Merry Christmas to you too! I haven’t had a FISH test since my diagnosis one month ago, but it was 96%.

Thanks for all your support and advice. It means

by scuba (Dec 25)

Your Neutrophils are low, but not dangerous. You should stay off sprycel until your neutrophils rise above 1.0 - 1.2. Your red blood cells are a bit low as well, but I suspect that is your system re

by Tater1 (Dec 24)

Hi everyone! Happy Holidays to you all....
I have been on 100 mg Sprycel for three weeks, and due to neutropenia, I am on a medication freeze until my counts are back up. I do
Category: Blood tests

Replies: 2

Last updated: 25 December 2019
joansullivan031278 on 21 December 2019

Category: Blood tests

Replies: 1

Last updated: 21 December 2019

Call from Oncologist said beginning stages of CML scared
by David Fitz (Dec 21)

Hi Joan,
Are these figures at the point of diagnosis of CML? If so, they are very low
CML doesn’t run in families. It is genetic in nature, but isn’t passed from parent to child.

by joansullivan031278 (Dec 21)

B2a2 is% 0.115

B3a2 is% 0.097
I'm very scared. What happens next? Cancer runs very rampant in my family but no cml that I'm aware of. Any help is appreciated.
Category: Blood tests

Replies: 1

Last updated: 21 December 2019
Fillette on 3 December 2019

Category: Blood tests

Replies: 3

Last updated: 11 December 2019

Imatinib not working
by David Fitz (Dec 11)

Oh my goodness ... that is a massive difference. Congratulations - I’m thrilled for you. I know availability of TKIs other than imatinib is very difficult in Rwanda so I am so happy for you to

by Fillette (Dec 10)

Hi Evah,

Good to know there is someone from Rwanda on this platform and Thank you for reaching out.
After an investigation with the doctors and the pathologists, it turns out the

by EvaH (Dec 6)

hey there
I was diagnosed in Rwanda too and was recently out the hospital in Eastern Province! I know that some of the machines in Rwanda arent very sensitive to high counts or high PCR, or at least

by Fillette (Dec 3)

Hi Everyone,
I went to the Doctor last 2 weeks and he suggested that I reduce the dose to 200mg (I normally take 400mg Glivec) because my WBC was low. He also sent me to the Lancet
Category: Blood tests

Replies: 3

Last updated: 11 December 2019
ShawnJ on 6 December 2019

Category: Blood tests

Replies: 4

Last updated: 8 December 2019

BCR ABL Questions
by alexmcpee (Dec 8)

No worries Shawn,
Yes that must be frustrating. This site is invaluable isn’t it. The thing to take away is don’t worry about your low presentation as we’ve discussed. Think of

by ShawnJ (Dec 8)

David and Alex
Thanks for the replies.
David what I meant by minor was the P190 that alex spoke about. The results are above for that one.
I am frustrated mostly by the lack of knowledge by the

by alexmcpee (Dec 7)

Hi Shawn,
I wondered when I’d see another very low presenting PCR result. I was diagnosed at baseline 13 - 20%. It was so low the test was performed twice to rule out errors. It is unusual to

by David Fitz (Dec 7)

Hi Shawn,
A PCR result (PCR test measures BCR-Abl) of 9.54% is a pretty low result for the first one, but absolutely not unheard of.
However - and this can be the confusing bit - it doesn
Category: Blood tests

Replies: 4

Last updated: 8 December 2019
Jason Graves on 7 December 2019

Category: Blood tests

Replies: 4

Last updated: 8 December 2019

good news.
by ColoradoGuy (Dec 8)

Awesome! Very happy to hear that. Thank you for sharing.

by mamodei (Dec 7)

Great news! May her platelets get to a good level and stay there.

by alexmcpee (Dec 7)

That’s good news Jason. Stay strong mate through which I know is a shit show of a time. Hoping things become predictable for you all!
Alex

by AlastairC (Dec 7)

Hey Jason that is such good news. Long may it continue.
Category: Blood tests

Replies: 4

Last updated: 8 December 2019
Blarn on 3 December 2019

Category: Blood tests

Replies: 6

Last updated: 5 December 2019

Interpreting qPCR results
by Lucas (Dec 5)

Hi, david! Hope you're fine!! well, i had the trisomy 8, but it were on PH negative cells (healthy cells). If the trisomy is on PH positive cells, than you have a problem. that's a clonal

by David Fitz (Dec 4)

One of members, Lucas, had a Trimsomy 8 at one point (some years back). If you use the search function on this site and search for “Lucas trisomy” you’ll find his story. I heard

by Blarn (Dec 4)

Thank you all for replies. I didn't know that FISH results were the more important indicator at this stage. Was trying to understand why SCT would be a recommended option, reading about it was

by Antibody Boy (Dec 3)

Blarn, since the complex variant translocation was not observed at diagnosis but was subsequently observed via cytogenetic testing at 3 and 7 months along with trisomy 8 (do you know if your trisomy
Category: Blood tests

Replies: 6

Last updated: 5 December 2019
mamodei on 22 November 2019

Category: Blood tests

Replies: 2

Last updated: 25 November 2019

BCR-ABL1 0.08 at 6 months
by koralia.pappi (Nov 25)

Congrats! Great news :)

by David Fitz (Nov 24)

0.08% after 6 months of treatment is stellar! An “optimal” result it anything below 1%, so you are miles below that. In fact you are below the optimal result expected at 12 months.
Quite

by mamodei (Nov 22)

I got great news today. My PCR result is 0.08 at just shy of 6 months on treatment. News like this does help.
I started on nilotinib, but had trouble with side effects culminating in a
Category: Blood tests

Replies: 2

Last updated: 25 November 2019
koralia.pappi on 21 November 2019

Category: Blood tests

Replies: 2

Last updated: 24 November 2019

Eosinophils
by koralia.pappi (Nov 24)

Hi Labros,
Thanks for the reply

:-)
Well, my doctor indeed told me :"you worry too much"!
This woman, she is great, answering all kinds of weird questions, although I can be a pain in the a

by labros (Nov 22)

Hello Koralia,
I don't think you should worry about your eosinophils, since they are still very close to the normal range. My doctor have mentioned to me that increased eosinophils should alert

by koralia.pappi (Nov 21)

Hi all,
I have a quick question about my blood tests. I was diagnosed 6 months ago, and I'm on Tasigna. Last PCR (3.5 months) was 0.32%, which is pretty good. I am now waiting for my results of
Category: Blood tests

Replies: 2

Last updated: 24 November 2019